Evolutionary dynamics of abundant stop codon readthrough in Anopheles and Drosophila
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چکیده
Jungreis et al. p1 Evolutionary dynamics of abundant stop codon readthrough in Anopheles and Drosophila Irwin Jungreis, Clara S. Chan, Robert M. Waterhouse, Gabriel Fields, Michael F. Lin, Manolis Kellis MIT Computer Science and Artificial Intelligence Laboratory, 32 Vassar Street, Cambridge, Massachusetts 02139, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, Massachusetts 02142, USA; Department of Genetic Medicine and Development, University of Geneva Medical School, rue Michel-Servet 1, 1211, Geneva, Switzerland; Swiss Institute of Bioinformatics, rue Michel-Servet 1, 1211 Geneva, Switzerland; MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139; DNAnexus, Mountain View, CA 94040, USA.
منابع مشابه
Evolutionary Dynamics of Abundant Stop Codon Readthrough
Translational stop codon readthrough emerged as a major regulatory mechanism affecting hundreds of genes in animal genomes, based on recent comparative genomics and ribosomal profiling evidence, but its evolutionary properties remain unknown. Here, we leverage comparative genomic evidence across 21 Anopheles mosquitoes to systematically annotate readthrough genes in the malaria vector Anopheles...
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Ribosomes can read through stop codons in a regulated manner, elongating rather than terminating the nascent peptide. Stop codon readthrough is essential to diverse viruses, and phylogenetically predicted to occur in a few hundred genes in Drosophila melanogaster, but the importance of regulated readthrough in eukaryotes remains largely unexplored. Here, we present a ribosome profiling assay (d...
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Stop codon readthrough is used extensively by viruses to expand their gene expression. Until recent discoveries in Drosophila, only a very limited number of readthrough cases in chromosomal genes had been reported. Analysis of conserved protein coding signatures that extend beyond annotated stop codons identified potential stop codon readthrough of four mammalian genes. Here we use a modified t...
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